(PK/PD) Modeling of Anti-Neoplastic Agents

Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling of Anti-Neoplastic Agents

Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs.

Over the last decades, the interest in the relationships between the pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobial agents has increased and, therefore, the use of PK/PD indices and expressions has spread widely. The appropriate definition and use of these parameters is a matter of controversy. This paper contains a proposal to use PK/PD expressions for antimicrobial agents an...

Pharmacokinetic/Pharmacodynamic (PK/PD) Relationship-based Approach to Understand the Variability of Central Neurological Effects of Ethanol

Pharmacokinetic/pharmacodynamic (PK/PD) relationships describe the quantitative relationships between the drug-induced effects and the concurrent corresponding drug concentrations in an individual. Since a long time, rough qualitative relationships have been described between neurological presentation and plasma ethanol concentration in acute ethanol ingestion. However, to date, precise quantit...

Bridging the Gap between Preclinical and Clinical Studies Using Pharmacokinetic-Pharmacodynamic (PK-PD) Modeling: An Analysis of GDC-0973, a MEK Inhibitor

Purpose: GDC-0973 is a potent and selective MEK inhibitor. Pharmacokinetic-pharmacodynamic (PK-PD) modeling was used to relate GDC-0973 plasma and tumor concentrations, tumor pharmacodynamics (PD) and anti-tumor efficacy in order to establish pharmacokinetic endpoints and predict active doses in the clinic. Experimental Design: A PK-PD model was used to characterize GDC-0973 tumor disposition a...

Pharmacokinetic-pharmacodynamic Modeling of Antihypertensive Drugse

Knowledge of pharmacokinetic-pharmacodynamic (PK/PD) properties of antihypertensive drugs may optimize drug therapy of hypertension. PK/PD modeling in clinical research could contribute in drug development and clinical practice in several aspects, including an evaluation of the efficacy and safety of antihypertensive agents, enhancement of information during the development process, identificat...